Mutant p53: One, No One, and One Hundred Thousand
نویسندگان
چکیده
منابع مشابه
Mutant p53: One, No One, and One Hundred Thousand
Encoded by the mutated variants of the TP53 tumor suppressor gene, mutant p53 proteins are getting an increased experimental support as active oncoproteins promoting tumor growth and metastasis. p53 missense mutant proteins are losing their wild-type tumor suppressor activity and acquire oncogenic potential, possessing diverse transforming abilities in cell and mouse models. Whether various mut...
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atrial fibrillation (AF) is associated with a significant burden of morbidity and increased risk of mortality. Antiarrhythmic drug therapy remains a cornerstone to restore and maintain sinus rhythm for patients with paroxysmal and persistent AF based on current guidelines. However, conventional drugs have limited efficacy, present problematic risks of proarrhythmia and cause significant noncard...
متن کامل"One-thousand one... one-thousand two...": chronometric counting violates the scalar property in interval timing.
Weber's law applied to interval timing is called the scalar property. A hallmark of timing in the seconds-to-minutes range, the scalar property is characterized by proportionality between the standard deviation of a response distribution and the duration being timed. In this temporal reproduction study, we assessed whether the scalar property was upheld when participants chronometrically counte...
متن کاملOne hundred meters.
To walk 100 meters at 4 kilometers per hour (an average walking pace) takes about 1.5 minutes. What would prevent an oncologist investing this brief time in visiting a patient in the next building? It is not that oncologists as a group are uncaring. I can think of too many examples where the opposite is true. Was he too busy? Was he burned out? Did he feel guilty at having failed to control the...
متن کاملOne hundred years.
One of my earliest memories is of a tall, thin clergyman who arrived late for a meeting as I stood outside the Lodge room as an Entered Apprentice whilst the ceremony of a higher degree was in progress. He was the treasurer of the Lodge and his name was the Reverend Prebendary Charles Waton. He was the Vicar of St Benet Fink, Edmonton and was a Grand Officer. To me, he was a very important maso...
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ژورنال
عنوان ژورنال: Frontiers in Oncology
سال: 2015
ISSN: 2234-943X
DOI: 10.3389/fonc.2015.00289